Whoa, those are crazy letters! I think Alex is right about the Cherokee language.
Use google.com/ncr to force the English interface. ("ncr" means "No Country/Culture Redirect.")
If you want to force your browser's homepage to show Google in English, you will have to set your homepage to google.com/ncr in your browser's settings.
Edit: Google probably determines which default UI language to show based on your IP address. Your IP address probably geo-locates to a place where Cherokee is used by most of the people. For example, I am located in Korea, and I always get the Korean version of Google. However, if I set the Google settings to use the English UI, it uses English for that computer/browser. This requires browser cookies; do you have cookies enabled?
Also, if your browser explicitly sets your homepage to http://www.google.com/webhp?hl=chr then Google will dutifully display Cherokee.