Very often I see my friends are commenting on their friends photos, statuses, etc., but I'm not interested if these interactions are not between my friends (if I don't know both of them).
How do I hide it from my news feed once and for all?
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Try FB Purity... it lets you block all sorts of things. I don't know if it blocks exactly what you're asking for, but it supports regexes, so perhaps you can come up with one to block what you need.