In Gmail, I have a number of accounts that I can choose to send from. (Old e-mail address, one used just for gaming, one for my blog, etc.)
How can I have a unique signature for each depending on which I choose?
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Sign up to join this communityGoogle just released Rich Text signatures, which also includes the ability to have a unique signature for each From address.
Gmail also now supports a unique signature for each email address associated with your account. So, if you send mail using a custom "From:" address, you can use a different signature for that address. From the Settings page, you can edit the signature for each account by changing the email address that appears in the dropdown menu.
https://gmail.googleblog.com/2010/07/rich-text-signatures.html
Have you looked at canned responses;
https://gmail.googleblog.com/2008/10/new-in-labs-canned-responses.html
These can be used along with filters.