The Company I work for deals with many customer enquiries and we rely a lot on email correspondence. I know how to create a canned response in GMail and am aware of its filters, but I was wondering if there's a way for the canned response to only be sent out to the original email enquiry and NOT the consequent follow-up emails (this would get annoying for the receiver!). 

E.g. Whenever let's say an email comes from `[email protected]` we can trigger the canned response to get sent, but if that same email address is replying to add to his/her enquiry, then that same canned response would no longer be appropriate.

Is there a way for GMail to track follow-up emails for canned responses?