You could define different groups of labels like issue types, issue priorities, issue statuses, version tags, and maybe more. In order to be able to see instantly to which group a label belongs to you could use a naming convention like :.
Using such a naming convention should make managing Github issues much easier and helps others to "understand" issues much faster. Note that you can also assign colors to labels which can add even more to readability (I would use a specific color for each label group). But because you still have to assign/unassign those labels to/from issues manually you might want to keep the overall list of groups/labels small.
According to the scheme suggested above you might define groups and corresponding labels as follows.
'issue type' group
'issue priority' group
'issue status' group
(These labels describe an issue's state in a defined workflow.)
'issue information' group
'version tag' group